Ordering Recommendation

Preferred initial screening test for G6PD deficiency. For genetic testing in individuals of African descent, refer to Glucose-6-Phosphate Dehydrogenase (G6PD) 2 Mutations (0051684); for genetic testing in individuals with other high-risk ethnic backgrounds, refer to Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD) Sequencing (3004457).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Yellow (ACD solution A). Also acceptable: Green (sodium or lithium heparin), lavender (K2EDTA or K3EDTA), or pink (K2EDTA). Enzyme most stable in acid citrate dextrose (ACD).

Specimen Preparation

Do not freeze. Transport 3 mL whole blood. (Min: 1.5 mL heparin or EDTA collection tube; Min: 0.5 mL pediatric collection tube).

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Clotted, frozen, or hemolyzed specimens.

Remarks

Pediatric minimum 0.5 mL if collected and transported in a pediatric collection K2EDTA tube. ACD collection tubes should be filled to maximum collectible volume and are not recommended for pediatric specimen collection or preservation.

Stability

Ambient: 8 hours; Refrigerated: 1 week; Frozen: Unacceptable

Methodology

Quantitative Enzymatic Assay

Performed

Sun-Sat

Reported

1-3 days

Reference Interval

Effective November 17, 2014
9.9-16.6 U/g Hb

Interpretive Data



Compliance Category

FDA

Note

Patients who have recently received transfusions have normal donor cells that may mask G-6-PD deficient erythrocytes.

Hotline History

N/A

CPT Codes

82955

Components

Component Test Code* Component Chart Name LOINC
0080135 Glucose-6-Phosphate Dehydrogenase 32546-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • G-6-PD
  • G6PD Erythrocytes
  • RBC G6PD test
Glucose-6-Phosphate Dehydrogenase